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PANCREATIC POLYPEPTIDE
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DeCS
Descriptor
English
:
Pancreatic Polypeptide
Descriptor
Spanish
:
Polipéptido Pancreático
Descriptor
Portuguese
:
Polipeptídeo Pancreático
Synonyms
English
:
Pancreatic Polypeptide (PP)
Pancreatic Polypeptide Hormone
Pancreatic Prohormone
Tree Number:
D06.472.699.587.700
D12.644.400.600
D12.644.548.586.700
D12.776.631.650.600
Definition
English
:
A 36-amino acid pancreatic hormone that is secreted mainly by
endocrine cells
found at the periphery of the
ISLETS OF LANGERHANS
and adjacent to cells containing
SOMATOSTATIN
and
GLUCAGON
.
Pancreatic polypeptide
(PP), when administered peripherally, can suppress gastric secretion,
gastric emptying
, pancreatic enzyme secretion, and
appetite
. A lack of
pancreatic polypeptide
(PP) has been associated with
OBESITY
in rats and mice.
Pharmacological Action:
Gastrointestinal Agents
Hormones
History Note
English
:
79
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
22598
Unique Identifier:
D010191
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS